The coating of a surgical mesh with broad spectrum antibiotics has proven in multiple applications to inhibit colonization of bacteria at the surgical site thus significantly reducing post-surgery complications caused by bacterial infections. The most commonly used broad spectrum antibiotics used for this purpose are minocycline and rifampin. While the addition of these antibiotics to the surgical mesh offers significant benefits to the patient, the project teams needs to be prepared for the challenges presented by coating a surgical mesh with antibiotics.